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Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
15:33

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

Induction of antigen-specific immune tolerance by TGF-beta-induced CD4+Foxp3+ regulatory T cells

Huimin Fan, Julie Wang, Xiaohui Zhou

    International Journal of Clinical and Experimental Medicine
    |November 18, 2009
    PubMed

    Like natural CD4(+)CD25(+) Treg cells, TGF-beta-induced Treg cells also prevent allograft rejection in MHC-mismatched organ transplantation models. In analyzing this effect with greater detail, we determined that injection of TGF-beta-induced, alloactivated CD4(+)CD25(+) cells induces antigen-specific immune tolerance in vivo. Increased CD4(+)CD25(+) cells in recipients contribute to this immune tolerance. In addition, adoptive transfer of TGF-beta-induced CD4(+)CD25(+) cells did not result in significant toxic and side effects in recipients. These results indicate that TGF-beta-induced, alloactivated CD4(+)CD25(+) cells may provide a safe and effective approach to protect MHC-mismatched organ grafts from rejection in a clinical setting.

    Keywords:
    Foxp3ImmunoregulationTGF-βregulatory T cellstransplant tolerance

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