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Paradoxical myopic shift following cycloplegia in retinopathy of prematurity patients: a case series
Nikolas Js London1, Susan M Carden, William V Good
1Department of Ophthalmology, California Pacific Medical Center, 2340 Clay St. 5th Floor, San Francisco, CA 94115, USA. nik.london@gmail.com
Insights
Pediatric patients with retinopathy of prematurity (ROP) may experience a myopic shift after cycloplegia, leading to incorrect spectacle prescriptions and potential non-compliance. This finding highlights a new factor contributing to vision correction challenges in ROP patients.
Area of Science:
- Ophthalmology
- Pediatric Optometry
- Refractive Error Research
Background:
- Spectacle non-compliance is a significant issue in pediatric eye care.
- Potential causes include patient age, discomfort, and refractive error severity.
- Retinopathy of prematurity (ROP) presents unique challenges in refractive correction.
Observation:
- A prospective study examined 8 pediatric patients with ROP.
- Retinoscopic refraction was measured before and after cycloplegia.
- 11 out of 13 eyes showed a myopic shift post-cycloplegia.
Findings:
- The average myopic shift was -1.58 D (OD) and -1.54 D (OS).
- This unanticipated myopic shift can lead to inaccurate spectacle prescriptions.
- Ocular component contributions to refractive status differ in ROP eyes.
Implications:
- Inaccurate prescriptions can result in poor visual acuity correction.
- This may be a contributing factor to spectacle non-compliance in ROP patients.
- Further research is needed to understand refractive changes in ROP.
Introduction:
Spectacle non-compliance is a significant problem in pediatric patients, and may have a variety of consequences. Non-compliance with myopic refractive correction could be secondary to a variety of issues, including age, discomfort, gender, urban vs. rural residence, presenting visual acuity, and degree of refractive error. We observed a phenomenon in our pediatric patients with retinopathy of prematurity that may add another possible explanation: incorrect prescription due to measures of increased, rather than decreased, myopia after cycloplegia.
Case Presentation:
An unmasked, prospective study of 8 consecutive patients seen in a single practice. Retinoscopic refraction measurements were obtained before and after pharmacologic cycloplegia. In all 13 eyes, there was either no change (2 eyes) or a myopic shift (11 eyes) in the measured refractive error. The average change in refraction was -1.58 and -1.54 for the right and left eyes, respectively (range 0 to -3.00 OD and 0 to -3.00 OS).
Conclusions:
The contribution of ocular components to refractive status differs between ROP and non-ROP eyes. Unanticipated myopic shift following cycloplegia in ROP patients may result in inappropriate glasses prescription with poor correction of visual acuity. This may contribute to spectacle noncompliance in this group.
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