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Updated: Jun 18, 2026

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
Papillon-Lefèvre syndrome and squamous cell carcinoma: a case report
Sammy Al-Benna1, Raphael Hasler, Ingo Stricker
1Department of Plastic and Reconstructive Surgery, Department of Hand Surgery, Soft Tissue Tumour Reference Centre, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle-de-la Camp-Platz 1, 44789 Bochum, Germany. sammy.al-benna@ruhr-uni-bochum.de
Abstract:
Papillon-Lefèvre syndrome is a rare autosomal recessive genodermatosis characterised by palmoplantar hyperkeratosis and severe early-onset periodontitis. The development of malignant cutaneous neoplasms within the hyperkeratotic lesions of the syndrome is very rare. Here, we report on a 67-year-old German Caucasian male with Papillon-Lefèvre syndrome associated with recurrent squamous cell carcinoma. Treatment is symptomatic and not always satisfactory.
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