Nodular glomerulosclerosis in patients' without history of diabetes mellitus: a case report
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Updated: Jun 18, 2026

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
Published on: June 18, 2020
Imed Helal1, Rym Goucha, Cyrine Karoui
1Department of Internal Medicine A and Laboratory of Kidney Pathology 02, Charles Nicolle Hospital Boulevard 9 Avril. 1006 Tunis Tunisia. imedhelal@voila.fr
Introduction:
Diabetic nephropathy can occur during the course of both type1 and type 2 diabetes mellitus. The characteristic lesions are diffuse or nodular (Kimmelsteil-Wilson) diabetic glomerulosclerosis. The reported cases represent unusual presentations of diabetes mellitus.
Case Presentation:
We report the case of a 49-year-old man without prior history of diabetes mellitus who presented with rapidly progressive renal failure and whose renal biopsy revealed nodular (Kimmelsteil-Wilson) glomerulosclerosis lesions characteristic of diabetes.
Conclusion:
Renal manifestations of diabetes mellitus may antedate other more common presenting symptoms of this disease and we critically review the literature on this subject.
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