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Updated: Jun 18, 2026

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

[Specific immunotherapy in hay fever: a practical overview].

D Harder¹, P Schmid-Grendelmeier

¹Brunnenhof-Praxis, Gäuggelistrasse 20, Chur. dominik.harder@hin.ch

|November 18, 2009

Summary

Allergen-specific immunotherapy (SIT) effectively treats pollinosis (hay fever), benefiting over 80% of patients when properly managed. Ongoing research aims to further enhance SIT

Area of Science:

Allergy and Immunology
Clinical Medicine
Pharmacology

Background:

Pollinosis affects 20% of the Swiss population, with a significant increase in prevalence over the past century.
Current diagnosis relies on medical history, skin tests, and serum-specific IgE.
Standard treatments include allergen avoidance, medication, and allergen-specific immunotherapy (SIT).

Purpose of the Study:

To review the efficacy and current status of allergen-specific immunotherapy for pollinosis.
To highlight factors critical for successful SIT.
To discuss emerging approaches for improving SIT.

Main Methods:

Review of existing literature on pollinosis diagnosis and treatment.
Analysis of factors influencing SIT success, including patient selection and application regimens.

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Exploration of novel diagnostic and therapeutic strategies, such as component-resolved diagnosis and molecular technologies.

Main Results:

SIT is highly effective, providing benefits for over 80% of pollinosis patients under optimal conditions.
Proper patient selection, allergen extract choice, adapted regimens, and patient guidance are crucial for successful SIT.
Component-resolved diagnosis offers a more precise diagnostic approach.

Conclusions:

Allergen-specific immunotherapy is a beneficial treatment for a majority of pollinosis patients.
Optimizing patient and allergen selection, application, and guidance enhances SIT efficacy.
Emerging molecular technologies and modified application regimens hold promise for improving SIT's effectiveness, safety, and patient acceptance.