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Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid
Patrick R Verhoest1, Caroline Proulx-Lafrance, Michael Corman
1Neuroscience Chemistry, Pfizer Global Research and Development, Groton, CT 06340, USA.
Abstract:
By use of chemical enablement and prospective design, a novel series of selective, brain penetrant PDE9A inhibitors have been identified that are capable of producing in vivo elevations of brain cGMP.
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