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Association between hyperuricemia and hypertension in a Chinese population at a high risk of hypertension

Zhen Sui Lu1, Zhen Hong Lu, Hang Lu

  • 1Department of Orthopedic Surgery, Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.

Blood Pressure
|November 19, 2009
PubMed

Insights

This study found that high uric acid levels (hyperuricemia) are linked to a greater risk of hypertension in Chinese adults at high cardiovascular risk. Managing uric acid may help prevent high blood pressure.

Area of Science:

  • Cardiology
  • Nephrology
  • Metabolic Syndrome

Background:

  • Hypertension is a major global health concern, particularly in Asian populations.
  • Hyperuricemia, elevated uric acid levels, is increasingly recognized as a potential risk factor for cardiovascular diseases.

Purpose of the Study:

  • To investigate the association between hyperuricemia and hypertension in a Chinese population at high risk for cardiovascular disease.
  • To determine if elevated uric acid levels predict the incidence of hypertension in this demographic.

Main Methods:

  • A cross-sectional study involving 813 Chinese patients with suspected cardiovascular disease.
  • Blood pressure was measured three times; participants were categorized as hypertensive (n=311) or non-hypertensive (n=502).
  • Clinical and biochemical variables, including uric acid levels, were analyzed using logistic regression.

Main Results:

  • Hypertensive subjects had significantly higher levels of uric acid, fasting glucose, LDL-cholesterol, total cholesterol, and urea nitrogen (p<0.05).
  • Individuals with uric acid >400 micromol/l had an odds ratio of 2.09 (95% CI 1.13-3.88) for hypertension compared to those with <200 micromol/l.
  • An odds ratio of 1.73 (95% CI 1.05-2.85) was observed for uric acid levels between 200-400 micromol/l.

Conclusions:

  • Hyperuricemia is significantly associated with hypertension in a Chinese population at high risk for cardiovascular disease.
  • Higher uric acid concentrations correlate with an increased risk of developing hypertension.
  • While age-adjusted analysis showed some attenuation, the link between uric acid and hypertension remains noteworthy.

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