Related Experiment Video
Updated: Jun 18, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
Published on: June 6, 2025
Effect of device-guided breathing exercises on blood pressure in patients with hypertension: a randomized controlled
Mariette R Altena1, Nanne Kleefstra, Susan J Logtenberg
1Diabetes Centre, Isala Clinics, Zwolle, The Netherlands.
Objective:
Hypertension is a chronic disorder with a high prevalence worldwide. Despite considerable efforts, it is sometimes hard to reach treatment goals for blood pressure (BP) with classical treatment options. Reducing breathing frequency has been advocated as a method to reduce BP.
Methods:
A randomized, single-blind, controlled trial was conducted in 30 non-diabetic patients with hypertension over a period of 9 weeks to evaluate the effect of a device that helps to slow breathing (Resperate) on BP and quality of life (QoL). The control group listened to music and used no other therapeutic device.
Results:
There was no significant difference in change in BP between intervention and control; BP -4.2 mmHg (95% CI -12.4 to 3.9)/-2.6 mmHg (95% CI -8.4 to 3.3). This result did not alter in post hoc analyses, when patients not achieving target breathing frequency (<10 breaths/min) or non-compliant patients were excluded. QoL did not change over time.
Conclusions:
We found no effect of the Resperate on BP or QoL compared with the control group. We conclude that, at this moment, this device has no added value in the treatment of hypertension.
Related Concept Videos
Pre-Procedural Guidelines for Assessing Blood Pressure
Errors occurring during blood pressure monitoring
Several factors...
Special considerations while measuring blood pressure
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Assessment of blood pressure in brachial artery(two-step method)
Measurement of Blood Pressure
Assessment of blood pressure in brachial artery(one-step method)
Prepare for the Procedure:
