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Ketamine cystitis as a mimic of carcinoma in situ
Jon D Oxley1, Angela M Cottrell, Susan Adams
1Department of Cellular Pathology, Southmead Hospital, Bristol, UK. jon.oxley@nbt.nhs.uk
Aims:
To describe the histopathological features of a series of patients with ketamine-related cystitis.
Methods And Results:
Seventeen patients with ketamine-related cystitis, who had undergone biopsy, were identified and reviewed. Twelve showed ulceration with significant urothelial atypia. In 10 of these, immunohistochemistry was performed; 9/10 had high p53 immunoreactivity and 7/10 had moderate to high levels of Ki67 reactivity, but all were negative for cytokeratin 20.
Conclusions:
Ketamine can lead to reactive urothelial changes that can mimic carcinoma in situ, but the long-term cancer risk remains unknown.
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