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Cerebellar apparent diffusion coefficient changes in patients with supratentorial ischemic stroke.

Y Liu1, J Nuutinen, M P Laakso

  • 1Department of Clinical Radiology, University of Kuopio, Kuopio University Hospital, Kuopio, Finland. Yawu.Liu@kuh.fi

Acta Neurologica Scandinavica
|November 19, 2009
PubMed
Summary
This summary is machine-generated.

Supratentorial ischemic stroke causes mild cerebellar vasogenic edema, indicated by increased apparent diffusion coefficient (ADC) values in cerebellar subregions within 48 hours and on day 8 post-stroke.

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Area of Science:

  • Neuroimaging
  • Cerebrovascular diseases
  • Diffusion-weighted imaging

Background:

  • Ischemic stroke can affect brain structures beyond the primary lesion site.
  • Cerebellar involvement in supratentorial strokes is not fully understood.
  • Diffusion parameters may reflect early pathophysiological changes.

Purpose of the Study:

  • To evaluate apparent diffusion coefficient (ADC) changes in cerebellar subregions following supratentorial ischemic stroke.
  • To compare ADC values between stroke patients and healthy controls.
  • To assess the temporal evolution of these changes.

Main Methods:

  • Diffusion-weighted imaging (DWI) and ADC mapping were performed on 20 supratentorial ischemic stroke patients within 48 hours and on day 8.
  • ADC values were measured in cerebellar white matter and gray matter subregions (medial, intermediate, lateral).
  • 15 age-matched healthy controls were included for comparison.

Main Results:

  • Increased ADCs were observed bilaterally in lateral cerebellar zones (G3) within 48 hours.
  • On day 8, ADCs were significantly increased in all contralateral cerebellar subregions and ipsilateral medial (G1) and intermediate (G2) zones.
  • Asymmetry indices of ADC correlated with SPECT findings, particularly in G3.

Conclusions:

  • Supratentorial ischemic stroke is associated with mild cerebellar vasogenic edema.
  • ADC changes in cerebellar subregions suggest early pathophysiological alterations.
  • These findings highlight potential secondary effects of stroke on cerebellar structures.