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Updated: Jun 18, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
Published on: February 9, 2011
Hospitalization of paediatric patients for methicillin-resistant Staphylococcus aureus skin and soft-tissue
K D Sircar1, E Bancroft, D M Nguyen
1Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. ddq0@cdc.gov
Abstract:
Hospital discharge reports have provided data for studies of methicillin-resistant Staphylococcus aureus (MRSA) skin and soft-tissue infection (SSTI) studies. This analysis determined the sensitivity and positive predictive value of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code combinations to calculate hospitalization incidence rates, representativeness of a set of three ICD-9-CM codes to define MRSA SSTI, and hospitalization incidence rate trends for paediatric MRSA SSTIs in Los Angeles County (LAC). Using 133 cases from 31 hospitals, we found that the set of three ICD-9-CM codes used to define laboratory-confirmed cases had one of the highest positive predictive values (49%). There was no difference in age and race between those categorized using three codes vs. other code combinations. A dramatic increase in paediatric MRSA SSTI cases occurred in LAC during 1998-2006. We conclude that this combination of codes may be used to determine the rise of MRSA SSTIs in paediatric populations.
Insights
Hospital discharge reports can track pediatric methicillin-resistant Staphylococcus aureus (MRSA) skin and soft-tissue infections (SSTIs). A specific set of three ICD-9-CM codes accurately identifies MRSA SSTI hospitalizations, revealing a significant increase in cases.
Area of Science:
- Infectious Diseases
- Public Health Surveillance
- Medical Informatics
Background:
- Hospital discharge reports are a data source for studying methicillin-resistant Staphylococcus aureus (MRSA) skin and soft-tissue infections (SSTIs).
- Accurate identification of MRSA SSTI hospitalizations is crucial for understanding disease trends.
Purpose of the Study:
- To determine the sensitivity and positive predictive value of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code combinations for MRSA SSTI hospitalization rates.
- To assess the representativeness of a specific set of three ICD-9-CM codes for defining MRSA SSTI.
- To analyze hospitalization incidence rate trends for pediatric MRSA SSTIs in Los Angeles County (LAC).
Main Methods:
- Analysis of 133 laboratory-confirmed MRSA SSTI cases from 31 hospitals in Los Angeles County.
- Evaluation of the positive predictive value of a specific combination of three ICD-9-CM codes.
- Comparison of demographic data (age, race) between cases identified by three codes versus other code combinations.
Main Results:
- The set of three ICD-9-CM codes demonstrated a high positive predictive value (49%) for identifying MRSA SSTI cases.
- No significant differences in age or race were observed between patients identified using the three-code set and those identified by other combinations.
- A substantial increase in pediatric MRSA SSTI hospitalizations was observed in LAC between 1998 and 2006.
Conclusions:
- The evaluated combination of three ICD-9-CM codes is a reliable method for identifying MRSA SSTI hospitalizations in pediatric populations.
- This coding strategy can be effectively utilized to monitor the incidence and trends of pediatric MRSA SSTIs.
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