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Updated: Jun 18, 2026
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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
Tuberculosis-related deaths without treatment.
1International Union Against Tuberculosis and Lung Disease, Paris, France. cychiang@theunion.org
Summary
Many tuberculosis (TB) patients, especially older adults or those with severe illness, did not receive timely treatment. This lack of treatment significantly increased mortality risk in this vulnerable TB patient group.
Area of Science:
- Public Health
- Infectious Diseases
- Epidemiology
Background:
- Tuberculosis (TB) remains a significant global health challenge, necessitating effective treatment strategies.
- Understanding factors influencing treatment initiation is crucial for improving patient outcomes.
Purpose of the Study:
- To identify factors associated with not receiving anti-tuberculosis treatment among notified TB patients.
- To determine the outcomes of TB patients who did not receive treatment.
Main Methods:
- Retrospective analysis of 536 culture-positive TB patients notified in Taipei in 2003.
- Multivariate analysis to identify predictors of not receiving anti-tuberculosis treatment.
- Comparison of mortality and follow-up outcomes between treated and untreated patients.
Main Results:
- 94.6% of TB patients received anti-tuberculosis treatment; 5.4% did not.
- Among untreated patients, 89.7% died, 6.9% were re-notified, and 3.5% were lost to follow-up.
- Older age (≥65 years), negative/undone sputum smears, sepsis, respiratory failure, and liver diseases were associated with lower likelihood of receiving treatment.
Conclusions:
- A significant proportion of TB patients did not receive timely treatment, particularly vulnerable groups.
- Lack of anti-tuberculosis treatment is strongly associated with increased mortality in TB patients.
- Targeted interventions are needed to ensure treatment access for high-risk TB patient populations.
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