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Related Concept Videos

Characteristics and Nomenclature of Copolymers01:24

Characteristics and Nomenclature of Copolymers

Copolymers are the products obtained from the polymerization of multiple monomer species. So, in a polymer chain itself, there can be multiple repeating units that come from different monomers. The process of synthesizing a polymer from different monomer species is called copolymerization. When two monomers are involved, the polymer is known as a bipolymer. Polymers with three and four monomers are termed terpolymers and quaterpolymers, respectively. Figure 1 depicts the copolymerization of...
Step-Growth Polymerization: Overview01:03

Step-Growth Polymerization: Overview

Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...
Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
Polymer Classification: Architecture01:14

Polymer Classification: Architecture

Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...

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Updated: Jun 18, 2026

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides
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HPMA copolymers: origins, early developments, present, and future.

Jindrich Kopecek1, Pavla Kopecková

  • 1Department of Pharmaceutics and Pharmaceutical Chemistry, Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112, USA. Jindrich.kopecek@utah.edu

Advanced Drug Delivery Reviews
|November 19, 2009
PubMed
Summary

N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers show promise as drug carriers for cancer and biomaterials. Research focuses on developing advanced macromolecular therapeutics and smart hydrogels for improved treatments.

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Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides
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10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers have emerged as a significant class of polymers.
  • Their unique properties make them suitable for various biomedical applications.
  • Previous research has explored their potential in drug delivery and biomaterial development.

Purpose of the Study:

  • To provide a comprehensive overview of HPMA copolymer research, focusing on synthesis, biological properties, and applications.
  • To highlight the development of HPMA copolymers as macromolecular therapeutics for cancer and musculoskeletal diseases.
  • To explore the use of HPMA copolymers in creating advanced biomaterials and smart hydrogels.

Main Methods:

  • Review of synthesis strategies for HPMA copolymers.
  • Evaluation of biological properties, including drug conjugation and release.
  • Investigation of HPMA copolymers as building blocks for biomaterials and hydrogels.
  • Surface modification of biomaterials and proteins using HPMA copolymers.

Main Results:

  • HPMA copolymers demonstrate potential as effective carriers for anticancer drugs.
  • Semitelechelic poly(HPMA) and HPMA copolymers are useful for modifying biomaterial and protein surfaces.
  • Hybrid block and graft HPMA copolymers can self-assemble into smart hydrogels.
  • The research contributes to the development of novel macromolecular therapeutics.

Conclusions:

  • HPMA copolymers represent a versatile platform for developing advanced drug delivery systems and biomaterials.
  • Further research into second-generation macromolecular therapeutics based on HPMA copolymers is warranted.
  • HPMA copolymers offer significant potential for treating cancer and musculoskeletal diseases and for designing innovative biomaterials.