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Related Concept Videos

Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
What is Gene Expression?01:36

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...

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Related Experiment Video

Updated: Jun 18, 2026

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
12:54

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Published on: March 7, 2018

Dynamism in gene expression across multiple studies.

Alexander A Morgan1, Joel T Dudley, Tarangini Deshpande

  • 1Stanford Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA 94305, USA.

Physiological Genomics
|November 19, 2009
PubMed
Summary
This summary is machine-generated.

This study introduces novel methods for analyzing gene expression dynamics, revealing conserved patterns across species and links to disease genes. These findings offer new perspectives on gene regulation and microarray analysis.

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Studying Muscle Transcriptional Dynamics at Single-molecule Scales in Drosophila
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Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Gene expression dynamics, or how and when genes change expression, are crucial for biological functions.
  • Existing methods for analyzing gene expression often focus on absolute variation or tissue breadth, potentially missing dynamic patterns.

Purpose of the Study:

  • To develop and apply novel methods for examining gene expression dynamics.
  • To characterize gene expression dynamics across multiple experimental conditions.
  • To explore the functional and regulatory implications of observed dynamic patterns.

Main Methods:

  • Developed new quantitative measures for gene expression dynamics.
  • Performed a large-scale meta-analysis of over 29,000 microarrays.
  • Analyzed gene expression patterns across human, mouse, and rat species.

Main Results:

  • Identified conserved patterns of gene expression dynamism across three species.
  • Found associations between specific dynamism patterns and known disease-related genes.
  • Demonstrated that differences in expression dynamics correlate with transcription factor binding sites and enriched functional gene sets.

Conclusions:

  • The developed methods provide a new way to characterize gene expression dynamics, complementing existing approaches.
  • Conserved dynamism patterns suggest fundamental biological roles and potential links to disease.
  • Understanding expression dynamics can inform gene selection for microarray design and data interpretation.