Related Experiment Video
Updated: Jun 18, 2026

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
Published on: October 5, 2018
Effect of chronic apraclonidine treatment on intraocular pressure in advanced glaucoma
U F Cardakli1, B A Smythe, J R Eisele
1Department of Ophthalmology, University of Wisconsin, Madison, Wisconsin, U.S.A.
Summary:
The efficacy of twice-daily treatment with 0.5% apraclonidine drops was evaluated retrospectively in patients with uncontrolled advanced glaucoma who were poor surgical candidates and on maximal tolerated medical therapy. Fifty-eight eyes of 48 patients were treated chronically with apraclonidine and had no additional concurrent pharmacologic or laser or surgical manipulations. The mean baseline intraocular pressure was 30.0 $pM 1.1 mm Hg. The mean percentage of decrease in intraocular pressure in the various diagnostic groups ranged from 13.6 to 30.8% at the first follow-up visit and from 23.2 to 37.3% at peak reduction. Eighty-one percent of the patients with baseline intraocular pressure >21 mm Hg showed =5 mm Hg decrease, and 75% showed a reduction =20%; 48% of the latter sustained the =20% response for at least 4 weeks and 43% for at least 8 weeks. Primary and secondary glaucomas did not differ in magnitude and duration of response, but developmental and congenital glaucomas responded less well. Intermediate or long-term apraclonidine therapy may be a reasonable alternative in selected glaucoma patients.
Related Concept Videos
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
Glaucoma: Overview
Ophthalmic Drug Delivery Systems
Indirect-Acting Cholinergic Agonists: Pharmacological Actions
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors