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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Videos

Trabeculectomy with mitomycin C for normal-tension glaucoma.

T Yamamoto1, M Ichien, H Suemori-Matsushita

  • 1Department of Ophthalmology, Gifu University School of Medicine, Gifu, Japan.

Journal of Glaucoma
|November 19, 2009
PubMed
Summary
This summary is machine-generated.

Trabeculectomy with mitomycin C effectively lowered intraocular pressure in normal-tension glaucoma patients. This surgical approach shows promise for managing this condition, with most patients achieving beneficial pressure levels.

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Surgical Interventions

Background:

  • Normal-tension glaucoma (NTG) presents a diagnostic and therapeutic challenge.
  • Elevated intraocular pressure (IOP) is a primary risk factor for glaucoma, but NTG occurs despite statistically normal IOP.
  • Effective IOP reduction is crucial for managing NTG progression.

Purpose of the Study:

  • To prospectively evaluate the efficacy and safety of trabeculectomy with mitomycin C in NTG patients.
  • To assess postoperative intraocular pressure (IOP) levels, visual function, and complications.

Main Methods:

  • A prospective study involving 31 patients (31 eyes) with NTG.
  • Trabeculectomy with 0.4 mg/ml mitomycin C was performed.
  • Patients were followed for 14-35 months (mean 24.4 months).

Main Results:

  • Mean IOP decreased from 14.1 mmHg preoperatively to 8.4 mmHg postoperatively.
  • 87% of patients achieved final IOP between 5-12 mmHg.
  • Visual acuity deterioration occurred in 7 eyes due to cataract; visual fields worsened in 2 eyes (6%). Hypotonous maculopathy occurred in 10% of eyes.

Conclusions:

  • Trabeculectomy with mitomycin C is a potentially effective surgical option for NTG.
  • The procedure achieved IOP levels considered beneficial for managing NTG in most patients.
  • Careful monitoring for complications such as cataract and hypotony is warranted.