Comparative Efficacy of the SLT versus LASAG Nd: YAG Delivery Systems in Rabbits

Area of Science:

• Ophthalmology
• Medical Devices
• Laser Therapy

Background:

• Transscleral cycloablation is a procedure to reduce intraocular pressure.
• Different laser delivery systems may impact treatment efficacy.
• Comparing laser delivery systems is crucial for optimizing glaucoma treatment.

Purpose of the Study:

• To compare the efficacy of two contact transscleral Nd:YAG laser delivery systems.
• To evaluate a synthetic sapphire-tipped laser probe (Surgical Laser Technologies - SLT) versus a quartz fiberoptic tip (LASAG Microrupter III).

Main Methods:

• Transscleral cycloablation was performed on pigmented rabbits using either the LASAG or SLT laser system.
• Specific energy settings (3.2 W, 0.5 s for LASAG; 3.0 W, 0.5 s for SLT) were applied.

Main Results:

• Both laser delivery systems effectively reduced intraocular pressure in rabbits.
• The maximum intraocular pressure reduction was -15.09 mm Hg with LASAG and -13.16 mm Hg with SLT.
• The duration of pressure reduction was not statistically different between the two groups (p = 0.83).

Conclusions:

• The LASAG and SLT transscleral Nd:YAG laser delivery systems are equally effective for lowering intraocular pressure in rabbits.
• Histological examination of ciliary processes and surrounding ocular tissues was conducted.