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Related Experiment Video

Updated: Jun 18, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Gadolinium-associated nephrogenic systemic fibrosis.

June M McKoy1, Anne Laumann, Athena Samaras

  • 1The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL.

Community Oncology
|November 19, 2009
PubMed
Summary
This summary is machine-generated.

Physicians should limit magnetic resonance imaging (MRI) scans for patients with kidney problems. This is due to potential toxicity risks associated with gadolinium-based contrast agents, which may cause serious health issues.

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Area of Science:

  • Radiology
  • Nephrology
  • Toxicology

Background:

  • Magnetic Resonance Imaging (MRI) is a common diagnostic tool.
  • Gadolinium-based contrast agents (GBCAs) are frequently used in MRI.
  • Concerns exist regarding potential adverse effects of GBCAs, particularly in patients with impaired kidney function.

Purpose of the Study:

  • To review the risks associated with gadolinium-based contrast agents.
  • To provide guidance on the judicious use of MRI in patients with renal dysfunction.
  • To emphasize the importance of essential diagnostic information for ordering MRI.

Main Methods:

  • Literature review of studies on gadolinium toxicity.
  • Analysis of clinical guidelines for MRI use in renal impairment.
  • Discussion of risk-benefit assessment for contrast-enhanced MRI.

Main Results:

  • Gadolinium deposition in the body has been reported following GBCA administration.
  • Nephrogenic systemic fibrosis (NSF) is a severe complication linked to older GBCAs in patients with severe renal dysfunction.
  • Long-term effects of gadolinium retention are still under investigation.

Conclusions:

  • Physicians should exercise caution when ordering MRI scans with GBCAs for patients with renal dysfunction.
  • MRI should only be performed if the diagnostic information is essential and cannot be obtained otherwise.
  • Alternative imaging modalities or non-contrast MRI should be considered when feasible.