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Updated: Jun 18, 2026

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
Published on: December 30, 2016
Detection of polyunsaturated omega-6 fatty acid in human malignant prostate tissue by 1D and 2D high-resolution magic
Katarina Stenman1, Jón B Hauksson, Gerhard Gröbner
1Department of Radiation Sciences, Diagnostic Radiology, Umeå University and University Hospital of Northern Sweden, Umeå, 901 87 Sweden. katarina.stenman@sidb.diagrad.umu.se
Object:
Polyunsaturated omega-6 fatty acids (PUFAs) have been shown to promote prostate cancer. Here, we describe the use of HRMAS NMR spectroscopy to detect omega-6 PUFA species in prostate tissues.
Materials And Methods:
Samples originating from non-malignant (n = 54) and malignant (n = 27) prostate tissues (from 27 prostatectomized men) were studied by 1D (1)H, 2D (1)H-(1)H and (1)H-(13)C HRMAS NMR spectroscopy followed by histopathological characterization.
Results:
HRMAS NMR proved to be a powerful, non-destructive method to identify and characterize PUFAs. The omega-6 PUFA was found in 15% of examined human prostate tumors.
Conclusion:
It is possible to detect PUFAs in prostate tissues using our NMR-based spectroscopic approach.
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