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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
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Odontoid metastasis: a potential lethal complication.

Faizal Rayan1, Cibu Mukundan, D D Shukla

  • 1Department of Trauma and Orthopaedics, Kettering General Hospital, Kettering, NN15 7LX, UK. rayanmarakkar@yahoo.co.uk

Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology
|November 19, 2009
PubMed
Summary
This summary is machine-generated.

Breast cancer commonly spreads to the cervical spine. This case highlights an atypical odontoid metastatic lesion in breast cancer, emphasizing early detection for better outcomes.

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Area of Science:

  • Oncology
  • Spine Surgery
  • Radiology

Background:

  • Cervical spine metastasis is common in advanced cancers, particularly breast malignancy.
  • Metastasis to the cervical spine significantly increases patient mortality.
  • Treatment aims to palliate pain, prevent fractures, and improve function.

Observation:

  • A 40-year-old woman with a history of breast cancer presented with neck and shoulder pain.
  • Initial cervical spine radiographs were normal; repeat imaging revealed a large lytic odontoid lesion.
  • Further investigations confirmed no other spinal metastases.

Findings:

  • Cyclical radiotherapy led to complete resolution of the odontoid peg lesion.
  • The patient remained clinically asymptomatic for 2 years post-treatment.
  • Metastatic lesions of the odontoid process are rare but significant.

Implications:

  • This case underscores the importance of considering atypical metastatic sites, such as the odontoid peg.
  • Early detection and prompt management of cervical spine metastases are crucial for patient survival and quality of life.
  • Radiotherapy can be an effective treatment for odontoid metastases, leading to favorable outcomes.