Related Experiment Video
Updated: Jun 18, 2026
An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
Published on: October 10, 2025
Neurofibromatosis with unilateral lower limb gigantism
Giacomo Sabbioni1, Nicola Rani, Valentina Devescovi
1Clinica Ortopedica e Traumatologica I, Laboratorio di Fisopatologia Ortopedica e Medicina Rigenerativa, Istituto Ortopedico Rizzoli, Università di Bologna, Via Pupilli 1, 40136, Bologna, Italy. giacomo.sabbioni@tkd.it
Abstract:
The case of a 3-year-old child diagnosed with Type 1 neurofibromatosis is presented, showing pigmented birthmarks and gigantism of the left lower limb associated with the presence of multiple neurofibromas. Increased bone growth appears to be the direct or indirect consequence of a still undefined paracrine effect of nerve tumor cells.
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