RNAi in X inactivation: contrasting findings on the role of interference
1Institute of Molecular Genetics, CNRS, UMR5535, 34293 Montpelier Cedex 5, France. satya.kota@igmm.cnrs.fr
Abstract:
X inactivation is the process that brings about the dosage equivalence of X-linked genes in females to that of males. This complex process initiated at a very early stage of female embryonic development is orchestrated by long non-coding RNAs transcribed in both sense and antisense orientation. Recent studies present contradicting evidence for the role of small RNAs and RNase III enzyme Dicer in the X inactivation process. In this review, I discuss these results in the overall perspective of X inactivation and gene silencing.
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