Related Experiment Video
Updated: Jun 18, 2026

A Rat Model of EcoHIV Brain Infection
Published on: January 21, 2021
Subcortical profile of memory compromise among HIV-1-infected individuals
Allen Schiller1, Jessica Foley, William Burns
1Harvard Medical School/McLean Hospital, Belmont, Massachusetts, USA.
Objective:
To examine the hypothesis of subcortical pathologic impairment in HIV/AIDS.
Method:
The study included 22 HIV+, 22 HIV- controls, 22 learning disordered (LD) HIV-, and 22 depressive HIV-. The groups were compared on eight WMS-III Indices.
Results:
Analyses revealed significantly lower scores (p < .05) in HIV+ on visual immediate memory, immediate memory, visual delayed memory, auditory delayed memory, working memory, and general memory. For all cases, HIV+ participants scored below the control group only.
Conclusions:
WMS-III indices discriminated HIV+ participants from normal comparisons. Inability to find differences between HIV+ and depressive and LD groups reflects the isolation of the subcortical effect to the HIV+ group.
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