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Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jun 18, 2026

Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells

Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells

Published on: May 20, 2020

Skin metastasis: a pathologist's perspective.

Mahmoud Rezk Abdelwahed Hussein¹

¹Department of Pathology, Assir Central Hospital, Kingdom of Saudi Arabia. mrcpath17@gmail.com

Journal of Cutaneous Pathology

|November 20, 2009

Summary

Skin metastasis, the spread of cancer to the skin, is uncommon but can be an early sign of internal malignancies. Understanding its patterns and presentation is crucial for diagnosis and patient outcomes.

Area of Science:

Oncology
Dermatology
Pathology

Background:

Skin metastasis signifies systemic cancer spread, originating from primary internal malignancies or skin cancers.
It represents an uncommon metastatic site, affecting 0.7-9% of cancer patients, often with a significant time lag after primary diagnosis.

Purpose of the Study:

To review literature on skin metastasis, including its incidence, patterns, and clinical presentation.
To share insights from 19 years of surgical pathology and dermatopathology experience with skin metastases.

Main Methods:

Literature review on skin metastasis.
Analysis of surgical pathology and dermatopathology case experience over 19 years.

Main Results:

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Skin metastases are rare but can be the first indicator of silent visceral cancers.

Metastasis patterns correlate with primary cancer type and patient sex, with lung and breast cancers being most common in men and women, respectively.

Lesions present as non-specific nodules, mimicking various dermatological conditions, and histologically resemble the primary tumor.

Conclusions:

Skin metastasis is a pre-terminal event associated with poor prognosis.
The process is complex, involving molecular interactions that are not fully understood.
Recognizing skin metastases is vital for early detection and management of underlying cancers.