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Decrease in plasma tryptophan after a tryptophan-free amino acid solution. A comparison between cirrhotic and control

E A Moja1, E Rocchi, F Benedetti

  • 1Chair of Psychobiology, Medical School, University of Modena, Italy.

Life Sciences
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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A tryptophan-free amino acid mixture lowers plasma tryptophan in healthy individuals by promoting protein synthesis. This effect is delayed and less pronounced in chronic liver disease patients, with severity correlating to the delay.

Area of Science:

  • Biochemistry
  • Gastroenterology
  • Clinical Nutrition

Background:

  • Amino acid mixtures, particularly those lacking tryptophan, reduce plasma tryptophan levels in healthy individuals.
  • This reduction is attributed to the stimulation of protein synthesis, leading to tryptophan incorporation into new proteins.
  • Chronic liver disease is associated with impaired protein synthesis, suggesting altered responses to amino acid challenges.

Purpose of the Study:

  • To investigate the effect of a tryptophan-free amino acid mixture on plasma tryptophan levels in patients with chronic liver disease.
  • To compare these effects with those observed in healthy controls.
  • To determine if the severity of liver disease influences the plasma tryptophan response.

Main Methods:

  • Administration of a tryptophan-free amino acid solution to healthy controls and patients with chronic liver disease (classified by Pugh modification of Child-Turcotte criteria).

Related Experiment Videos

  • Measurement of plasma total tryptophan levels at baseline and at 60, 120, and 210 minutes post-administration.
  • Fasting period of 12 hours for all participants prior to the study.

    • Main Results:

    • In healthy controls, plasma tryptophan significantly decreased post-administration, reaching 50% of baseline at 210 minutes.
    • In cirrhotics, the decrease in plasma tryptophan was significantly delayed compared to controls.
    • The delay in tryptophan reduction was proportional to the severity of liver disease, with less severe cases showing a slower decline than controls, and more severe cases showing minimal changes.

    Conclusions:

    • Tryptophan-free amino acid mixtures impact plasma tryptophan levels differently in chronic liver disease patients compared to healthy individuals.
    • Impaired protein synthesis in chronic liver disease alters the metabolic response to amino acid loading.
    • The severity of liver disease is a key factor in the delayed and attenuated plasma tryptophan decrease observed in these patients.