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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

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Updated: Jun 18, 2026

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
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The nuclear envelope as a signaling node in development and disease.

William T Dauer1, Howard J Worman

  • 1Department of Neurology, University of Michigan Medical School, Ann Arbor, MI 48109 USA. dauer@umich.edu

Developmental Cell
|November 20, 2009
PubMed
Summary

The nuclear envelope, crucial for eukaryotes, is more than a barrier. Its structure and proteins regulate cell complexity, development, and disease, revealing its role as a key signaling hub.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • The nuclear envelope's evolution marked the origin of eukaryotes, separating DNA from the cytoplasm.
  • Historically viewed as a passive barrier, its active roles in cellular organization are increasingly recognized.
  • Dysfunction in nuclear envelope proteins is linked to various human diseases, termed nuclear envelopathies or laminopathies.

Purpose of the Study:

  • To review recent advancements in understanding the nuclear envelope's structure and function.
  • To explore the connection between nuclear envelope proteins and cellular processes like development and differentiation.
  • To highlight insights gained from studying nuclear envelopathies.

Main Methods:

  • Literature review of recent research on the nuclear envelope.
  • Analysis of studies focusing on nuclear envelopathies and their genetic basis.
  • Integration of findings on nuclear envelope protein composition and function.

Main Results:

  • The nuclear envelope plays a fundamental role in cellular complexity and organization.
  • Alterations in nuclear envelope structure and protein composition are vital for metazoan development and differentiation.
  • Studies of nuclear envelopathies reveal novel functions of nuclear envelope proteins.

Conclusions:

  • The nuclear envelope is a dynamic structure with critical roles beyond compartmentalization.
  • Nuclear envelope proteins are essential signaling molecules involved in development and disease.
  • Emerging research positions the nuclear envelope as a central signaling node.