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Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
Published on: November 7, 2020
[Conversion to rapamycin in liver transpant recipients with renal insufficiency]
1Department of Gastrointestinal Surgery, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China. yusi1976111@yahoo.com.cn
Objective:
To investigate the efficacy of conversion from calcineurin-inhibitor (CNI) to rapamycin in liver recipients with CNI-associated renal insufficiency.
Methods:
This retrospective study examined the liver transplant recipients who had switched from CNI to rapamycin between January 2004 and June 2008 in the first affiliated hospital of Sun Yat-sen University. The data of renal function before and after the conversion were analyzed by Wilcoxon sum rank test, and rapamycin-related adverse effects were also observed.
Results:
Compared with that before conversion, the renal funtion 4 months after the conversion improved significantly (P<0.05). The blood lipid level 3 months after the conversion increased significantly (P<0.05) but were well controlled.
Conclusion:
Rapamycin can be used safely as a good alternative in liver transplant recipients with CNI-related renal insufficiency.
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