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Identification of Western equine encephalitis virus structural proteins that confer protection after DNA vaccination
Penelope J Gauci1, Josh Q H Wu, George A Rayner
1Biological Countermeasures, Human Protection and Performance Division, Defence Science & Technology Organisation, 506 Lorimer St., Fishermans Bend, VIC 3207, Australia. Penny.Gauci@dsto.defence.gov.au
Abstract:
DNA vaccines encoding different portions of the structural proteins of western equine encephalitis virus were tested for the efficacy of their protection in a 100% lethal mouse model of the virus. The 6K-E1 structural protein encoded by the DNA vaccine conferred complete protection against challenge with the homologous strain and limited protection against challenge with a heterologous strain.
