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Phenytoin toxicity due to interaction with clobazam
B Zifkin1, A Sherwin, F Andermann
1Département des Sciences Neurologiques, Hôpital du Sacré-Coeur de Montréal, Université de Montréal, PQ, Canada.
Neurology
|February 1, 1991
Summary
Adding clobazam to phenytoin treatment can cause phenytoin intoxication. Patients experienced symptoms and elevated phenytoin levels, which resolved upon dose reduction. This interaction highlights a potential risk when combining these antiepileptic drugs.
Area of Science:
- Pharmacology
- Clinical Neurology
- Drug Interactions
Background:
- Clobazam, a benzodiazepine antiepileptic drug (AED), is often added to existing AED regimens.
- Generally, clobazam is well-tolerated and does not cause significant toxicity when combined with other AEDs.