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Published on: June 13, 2022
Ugandenial A, a new drimane-type sesquiterpenoid from Warburgia ugandensis
Min Xu1, Marc Litaudon, Sabrina Krief
1Kunming Institute of Botany, Chinese Academy of Sciences, Heilongtan, Kunming 650204, China. xumin@mail.kib.ac.cn
Abstract:
One new drimane-type sesquiterpenoid, named ugandenial A (1), was isolated from the ethyl acetate extract of the bark of Warburgia ugandensis (Canellaceae) together with eight known drimane-type sesquiterpenoids: 11alpha-hydroxycinnamosmolide (2), warburganal (3), polygodial (4), mukaadial (5), dendocarbin A (6), 9alpha-hydroxycinnamolide (7), dendocarbin L (8) and dendocarbin M (9). Their structures were established by detailed spectroscopic analysis. In addition a keto-enol equilibrium was demonstrated for compound 1 through a detailed NMR analysis run in CD(2)Cl(2) at 190 K. Cytotoxicity of the isolated compounds against KB cells was evaluated.
