Is Peri-Operative Isolated Systolic Hypertension (ISH) a Cardiac Risk Factor?
1Department of Anesthesiology and Perioperative Medicine, University of Ottawa, 1053 Carling Ave. (B3), The Ottawa Hospital, Ottawa, Ontario, Canada, K1Y 4E9.
Insights
Isolated Systolic Hypertension (ISH) is a significant cardiovascular risk factor, particularly in the perioperative period. Further research is needed to understand its impact on surgical patients and improve outcomes.
Area of Science:
- Cardiology
- Geriatrics
- Anesthesiology
Background:
- Isolated Systolic Hypertension (ISH) is common in aging populations and linked to increased cardiac and cerebrovascular events.
- ISH is associated with left ventricular (LV) changes, including hypertrophy (LVH) and diastolic dysfunction (DD).
- Perioperative cardiac complications are a major concern, especially in lower-risk patients.
Purpose of the Study:
- To review Isolated Systolic Hypertension (ISH) as a cardiovascular risk factor.
- To emphasize the under-recognized role of ISH in the perioperative setting.
- To highlight the need for further investigation into perioperative ISH.
Main Methods:
- Literature review of Isolated Systolic Hypertension (ISH).
- Analysis of ISH's association with cardiovascular events and LV changes.
- Discussion of ISH in the context of perioperative cardiac complications.
Main Results:
- ISH is the most frequent hypertension subtype (65%) in uncontrolled cases and carries higher risks than diastolic hypertension.
- LVH and DD are common in ISH patients, increasing cardiovascular event risk.
- Essential hypertension is not a significant perioperative risk factor in most studies, but perioperative ISH is under-studied.
Conclusions:
- ISH is an under-recognized perioperative risk factor.
- Further research, such as the PROMISE Study, is crucial to understand and manage perioperative ISH.
- Managing elevated systolic blood pressure in ISH patients can reduce cardiovascular event risk.
Abstract:
We are presenting a review of Isolated Systolic Hypertension (ISH) as a cardiovascular risk factor with emphasis on the perioperative period.Isolated systolic hypertension is associated with aging and is the most frequent subtype (65%) among patients with uncontrolled hypertension. ISH is strongly associated with increased risks of cardiac and cerebrovascular events exceeding those in comparably aged individuals with diastolic hypertension. Patients with ISH show an increase in left ventricular (LV) mass and an increase in the prevalence of left ventricular hypertrophy (LVH). These LV changes increase cardiovascular events and frequently lead to diastolic dysfunction (DD). Treatment to reduce elevated systolic blood pressure has been shown to reduce the risk of cardiovascular events.In the perioperative setting, essential hypertension has not been found to be a significant risk factor for cardiac complications. Most of the studies were based on the definition of essential hypertension and underpowered in sample size. The significance of perioperative ISH, however, is not well studied, partly due to its recognition only fairly recently as a cardiovascular risk factor in the non-surgical setting, and partly due to the evolving definition of ISH.Perioperative cardiac complications remain a significant problem to the healthcare system and to the patient. Although the incidence of perioperative cardiac complications is prominent in high-risk patients as defined by the Revised Cardiac Risk Index (RCRI), the bulk of the cardiac complications actually occur in low-risk group. Currently, little understanding exists on the occurrence of perioperative cardiac complications in low- risk patients. A factor such as ISH, with its known pathophysiological changes, is a potential perioperative risk factor.We believe ISH is an under-recognized perioperative risk factor and deserves further studying. Our research group has recently been funded by the Heart Stroke Foundation (HSF) to examine ISH as a perioperative risk factor (PROMISE Study).
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