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Related Experiment Video

Updated: Jun 18, 2026

Transcriptome Profiling of In-Vivo Produced Bovine Pre-implantation Embryos Using Two-color Microarray Platform
09:04

Transcriptome Profiling of In-Vivo Produced Bovine Pre-implantation Embryos Using Two-color Microarray Platform

Published on: January 30, 2017

Transcriptome profiling of human pre-implantation development.

Pu Zhang1, Marco Zucchelli, Sara Bruce

  • 1Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden.

Plos One
|November 20, 2009
PubMed
Summary
This summary is machine-generated.

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This study reveals two key gene expression shifts during human preimplantation development, from maternal to embryonic gene control. These findings offer insights into early human development and conserved gene evolution.

Area of Science:

  • Developmental Biology
  • Genomics
  • Reproductive Science

Background:

  • Human preimplantation development is critical for early embryogenesis.
  • The molecular mechanisms governing this stage remain largely uncharacterized.

Purpose of the Study:

  • To investigate the transcriptional dynamics during human preimplantation development.
  • To identify key molecular transitions in early human embryogenesis.

Main Methods:

  • Microarray analysis was performed on 397 human oocytes and embryos.
  • Gene expression patterns were analyzed across six distinct developmental stages.

Main Results:

  • Two major transcriptional transitions were identified: maternal to embryonic gene expression shifts.

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Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

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Related Experiment Videos

Last Updated: Jun 18, 2026

Transcriptome Profiling of In-Vivo Produced Bovine Pre-implantation Embryos Using Two-color Microarray Platform
09:04

Transcriptome Profiling of In-Vivo Produced Bovine Pre-implantation Embryos Using Two-color Microarray Platform

Published on: January 30, 2017

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
12:09

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Published on: August 10, 2022

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos
08:50

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Published on: June 12, 2020

  • Maternal gene expression dominates early stages (oocyte to 4-cell), followed by embryonic gene activation (8-cell to blastocyst).
  • Human preimplantation development exhibits relative autonomy, with conserved gene expression patterns.

    • Conclusions:

    • The study provides a foundational dataset for understanding human preimplantation development.
    • Findings highlight conserved gene expression dynamics across species during early development.