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Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

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Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

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An Ex Vivo Model of Ovarian Cancer Peritoneal Metastasis Using Human Omentum

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Published on: January 26, 2024

Obesity and cancer.

R Percik¹, M Stumvoll

¹Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer, Israel.

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [And] German Diabetes Association

|November 20, 2009

Summary

Obesity is linked to a higher risk of several cancers, including colon, breast, and liver. Understanding the mechanisms behind this link is crucial for cancer prevention and research.

Area of Science:

Oncology
Epidemiology
Public Health

Background:

Obesity is a growing global health concern.
Epidemiological data indicate a correlation between obesity and increased incidence of various cancer types.
Potential mechanisms linking obesity to cancer are multifactorial.

Purpose of the Study:

To review the epidemiological evidence associating obesity with cancer risk.
To explore proposed biological and lifestyle mechanisms underlying this association.
To highlight the need for further research into obesity-related carcinogenesis.

Main Methods:

Literature review of epidemiological studies.
Synthesis of proposed etiological factors.
Identification of research gaps.

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Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

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Main Results:

Consistent associations found between obesity and cancers of the colon, esophagus, postmenopausal breast, endometrium, kidney, liver, gallbladder, and pancreas.
Proposed mechanisms include dietary factors, reduced physical activity, adipose tissue-derived factors, and precursor conditions like gallstones.
The causal relationship and specific mechanisms require further investigation.

Conclusions:

Obesity represents a significant, yet often overlooked, risk factor for multiple cancers.
Further research is warranted to elucidate the complex causality and mechanisms.
Addressing obesity may offer a viable strategy for cancer risk reduction.