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Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts
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FTO - Friend or foe?

D Tews1, P Fischer-Posovszky, M Wabitsch

  • 1Department of Pediatrics and Adolescent Medicine, University of Ulm, Germany. daniel.tews@uniklinik-ulm.de

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|November 20, 2009
PubMed
Summary
This summary is machine-generated.

The fat mass and obesity associated gene (FTO) is key for obesity. This review explores FTO's role in weight regulation and obesity, focusing on its central and peripheral effects, especially in adipose tissue.

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Area of Science:

  • Genetics and Molecular Biology
  • Obesity Research
  • Metabolic Disease

Background:

  • The fat mass and obesity associated gene (FTO) is the most significant polygene linked to obesity identified through genome-wide association studies.
  • Despite its strong association with body weight regulation, FTO's precise functional role in obesity pathogenesis is not fully understood.

Purpose of the Study:

  • To review the potential involvement of FTO in weight regulation and obesity development.
  • To highlight FTO's relevance in both central and peripheral tissues, with a particular emphasis on adipose tissue.

Main Methods:

  • Literature review of existing studies on FTO.
  • Analysis of rodent studies investigating FTO's role in food intake regulation.
  • Examination of research discussing peripheral FTO effects.

Main Results:

  • Rodent studies suggest a central role for FTO in regulating food intake.
  • Emerging evidence points to peripheral functions of FTO relevant to obesity.
  • Adipose tissue is identified as a key focus for FTO's influence on weight regulation.

Conclusions:

  • FTO plays a potentially significant role in the complex mechanisms of weight regulation and obesity.
  • Further research into FTO's central and peripheral actions, particularly in adipose tissue, is warranted to elucidate its full impact on obesity development.