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Updated: Jul 22, 2026

Three-Dimensional Reconstruction of Orbital Fractures
Published on: May 16, 2025
Complications of hydroxyapatite bone cement reconstruction of retrosigmoid craniotomy: two cases
Aaron G Benson1, Hamid R Djalilian
1Department of Otolaryngology-Head and Neck Surgery, University of Illinois at Chicago, Chicago, IL, USA.
Abstract:
Hydroxyapatite bone cement is a versatile material used to reconstruct many types of bony surgical defects, and its applications have been widely reported in the literature. Still, complications of its use do occur. We describe 2 cases of hydroxyapatite resorption and subsequent seroma formation in patients who had undergone retrosigmoid craniotomy. The presentation in both cases mimicked a CSF leak. In both cases, the fragmented cement was removed, and the patient experienced no further complications. While hydroxyapatite cement is a highly useful product for the reconstruction of some craniofacial or skull base defects, we believe that it should not be used for the reconstruction of retrosigmoid/suboccipital craniotomies because it is associated with unacceptably high complication rates. Surgeons must exercise caution in selecting candidates for hydroxyapatite reconstruction of cranial defects.