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Related Experiment Video

Updated: Jun 18, 2026

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

Peptide-functionalized thermo-sensitive hydrogels for sustained drug delivery.

Wei Xun¹, De-Qun Wu, Ze-Yong Li

¹Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, PR China.

Macromolecular Bioscience

|November 20, 2009

Summary

A novel thermo-sensitive hydrogel was synthesized using a KRGDKK peptide, showing potential for injectable drug delivery. This peptide-hydrogel system offers improved mechanical properties and sustained drug release for over a month.

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Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

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Published on: October 29, 2013

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

Biomaterials Science
Polymer Chemistry
Drug Delivery Systems

Background:

Development of advanced hydrogels for biomedical applications is crucial.
Thermo-sensitive polymers offer unique advantages for controlled release.
Peptide functionalization can enhance hydrogel properties and biocompatibility.

Purpose of the Study:

To synthesize a novel thermo-sensitive hydrogel functionalized with a KRGDKK peptide.
To investigate the self-assembly behavior and properties of the peptide-modified hydrogel.
To evaluate the potential of the hydrogel as an injectable drug-delivery system.

Main Methods:

Solid-phase synthesis of KRGDKK peptide.
Coupling of KRGDKK peptide to PCLA-PEG-PCLA triblock copolymer.
Investigation of copolymer self-assembly in aqueous solution.
Preparation and characterization of hydrogels.
In vitro cell viability and drug release studies.

Main Results:

Successful synthesis of peptide-PCLA-PEG-PCLA-peptide copolymer and hydrogels.
Peptide-functionalized hydrogels showed no apparent cytotoxicity.
Improved mechanical properties of peptide-PCLA-PEG-PCLA-peptide hydrogels due to hydrogen bonding.
Sustained in vitro drug release for over one month without initial burst.

Conclusions:

The synthesized peptide-PCLA-PEG-PCLA-peptide hydrogels are biocompatible and possess enhanced mechanical properties.
These hydrogels demonstrate significant potential as injectable drug-delivery systems with excellent controlled release capabilities.