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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

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Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods

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Published on: May 11, 2018

Two-step synthesis of multivalent cancer-targeting constructs.

Jill M Stukel¹, Ronald C Li, Heather D Maynard

¹School of Biological and Health Systems Engineering, Center for Interventional Biomaterials, Arizona State University, Tempe, Arizona, USA.

Biomacromolecules

|November 21, 2009

Summary

Researchers developed a rapid, two-step synthesis for targeted glioblastoma therapies. This new method efficiently creates multivalent constructs that specifically target cancer cells, offering a potentially low-cost solution for clinical applications.

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Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates

Published on: March 6, 2019

Area of Science:

Bioconjugation Chemistry
Nanomedicine
Oncology

Background:

Targeted delivery systems enhance therapeutic and imaging efficacy by utilizing ligands for overexpressed receptors on pathological cells.
Previous multivalent constructs targeting alpha(6)beta(1)-integrin for glioblastoma were effective but limited by inefficient solid-phase synthesis.
The need for cost-effective and scalable synthesis methods is crucial for clinical translation.

Purpose of the Study:

To develop and validate a novel, efficient two-step synthesis for creating multivalent constructs targeting glioblastoma cells.
To demonstrate the preferential targeting and safety profile of these newly synthesized constructs.
To establish a potentially low-cost and rapid method for producing targeted therapeutics for personalized medicine.

Main Methods:

Synthesis of a well-defined aldehyde side chain polymer.
Conjugation of alpha(6)beta(1)-integrin specific ligands using oxime chemistry.
Evaluation of constructs through competitive binding, fluorescence binding, and toxicity assays.

Main Results:

Successful proof-of-concept for a two-step synthesis of targeted constructs.
Demonstrated multivalent nature and preferential targeting of glioblastoma cells.
Established the non-toxic profile of the synthesized constructs in vitro.

Conclusions:

The developed two-step synthesis offers a rapid and potentially low-cost alternative for producing targeted glioblastoma therapeutics.
These novel constructs show promise for enhanced delivery and imaging in clinical settings.
This approach facilitates the advancement of targeted therapies and personalized medicine.