Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polyfunctional Ligand of the Clinical Setting: Thermodynamic Studies of the Equilibria of Tranexamic Acid in Aqueous Solutions.

ACS omega·2026
Same author

Environmentally relevant doses of gadolinium (GdCl<sub>3</sub>; Gd<sub>2</sub>O<sub>3</sub>) trigger immune and antioxidant effects in non-target organisms: Cellular and tissue responses in the gills of mussel Mytilus galloprovincialis.

Environmental research·2026
Same author

Characterizing resistance in prostate cancer at a single cell level with hormonal treatment and epigenetic inhibitors.

The Journal of pharmacy and pharmacology·2025
Same author

Biochemical Modification of Poly-Vinyl-Alcohol-Based Bioplastics with <i>Citrus</i> By-Product to Increase Its Food Packaging Application.

International journal of molecular sciences·2025
Same author

Precision epigenetic therapies in oncology.

Cancer metastasis reviews·2025
Same author

Ligands of Biological and Environmental Interest as Sequestering Agents for Fe<sup>3+</sup> in Aqueous Solution: A Speciation Study of Natural Fluids.

Molecules (Basel, Switzerland)·2025
Same journal

Emerging Frontiers in Nanomedicine for Colorectal Cancer: A Review of Therapeutic Advances, Clinical Evidence, and Patented Technologies.

Anti-cancer agents in medicinal chemistry·2026
Same journal

Microfluidic Synthesis of miR-10a Antisense Oligonucleotides-Loaded LNP Combined with Cisplatin for Colorectal Cancer Therapy.

Anti-cancer agents in medicinal chemistry·2026
Same journal

Synergistic Anticancer Effect of Luteolin and Etoposide via the PI3K/AKT Signaling Pathway.

Anti-cancer agents in medicinal chemistry·2026
Same journal

Targeting Eg5 with K858: A Strategy for Radiosensitization Through ROS-Mediated DNA Damage in Esophageal Squamous Cell Carcinoma.

Anti-cancer agents in medicinal chemistry·2026
Same journal

Pulsatilla chinensis Saponins as Multitargeted Anticancer Agents: A Mini-Review of Molecular Mechanisms and Therapeutic Potential.

Anti-cancer agents in medicinal chemistry·2026
Same journal

Efficacy and Safety of Pembrolizumab as Monotherapy and in Combination with Chemotherapy versus Chemotherapy Alone for Advanced Gastric or Gastroesophageal Junction Cancer: A Systematic Review and Meta-Analysis.

Anti-cancer agents in medicinal chemistry·2026
See all related articles

Related Experiment Video

Updated: Jun 18, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

Targeting prostate cancer stem cells.

Francesco Crea1, Lesley A Mathews, William L Farrar

  • 1Cancer Stem Cell Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland, USA.

Anti-Cancer Agents in Medicinal Chemistry
|November 21, 2009
PubMed
Summary
This summary is machine-generated.

Cancer stem cells drive tumor growth and relapse due to chemoresistance. Targeting these prostate cancer stem cells offers a path to more effective cancer therapies.

More Related Videos

Isolation of Stem-like Cells from 3-Dimensional Spheroid Cultures
09:06

Isolation of Stem-like Cells from 3-Dimensional Spheroid Cultures

Published on: December 13, 2019

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

Related Experiment Videos

Last Updated: Jun 18, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

Isolation of Stem-like Cells from 3-Dimensional Spheroid Cultures
09:06

Isolation of Stem-like Cells from 3-Dimensional Spheroid Cultures

Published on: December 13, 2019

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

Area of Science:

  • Oncology
  • Cancer Biology
  • Stem Cell Research

Background:

  • Cancer stem cells (CSCs) are a critical sub-population within tumors.
  • CSCs possess self-renewal and differentiation capabilities, driving tumorigenesis.
  • These cells exhibit resistance to conventional chemotherapy, leading to patient relapse.

Purpose of the Study:

  • To discuss the identification of prostate cancer stem cells (PCSCs).
  • To outline the unique biological properties of PCSCs.
  • To explore therapeutic strategies targeting PCSCs for improved treatment efficacy.

Main Methods:

  • Identification of prostate cancer stem cells.
  • Characterization of PCSC unique properties.
  • Review of potential therapeutic targets for PCSCs.

Main Results:

  • Prostate cancer stem cells identified as key drivers of tumor formation.
  • Unique self-renewal and differentiation properties of PCSCs confirmed.
  • Chemoresistance of PCSCs linked to therapeutic challenges and relapse.

Conclusions:

  • Targeting prostate cancer stem cells is crucial for overcoming treatment resistance.
  • Developing therapies focused on PCSCs may lead to more efficacious prostate cancer treatments.
  • Further research into PCSC biology can unlock novel therapeutic avenues.