Related Experiment Video
Updated: Jun 18, 2026
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Endothelial dysfunction in hemodialysis patients with failed renal transplants
Numan Gorgulu1, Berna Yelken, Yasar Caliskan
1Department of Internal Medicine, Division of Nephrology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. numangorgulu@gmail.com
Clinical Transplantation
|November 21, 2009
Summary
Endothelial dysfunction is more pronounced in patients with failed renal transplants on hemodialysis compared to those new to hemodialysis. This may be due to inflammation from the failed allograft, impacting cardiovascular health.
Area of Science:
- Cardiovascular Science
- Nephrology
- Vascular Biology
Background:
- Endothelial dysfunction (ED) is a key factor in cardiovascular events and atherosclerosis.
- Investigating ED in hemodialysis patients is crucial for understanding cardiovascular risk.
Purpose of the Study:
- To compare endothelial dysfunction (ED) using coronary flow reserve (CFR) between hemodialysis (nHD) patients and patients with failed renal transplants restarting hemodialysis (fTx-HD).
Main Methods:
- Cross-sectional study including 40 nHD and 43 fTx-HD patients.
- Assessed clinical and biochemical parameters, including high-sensitive C-reactive protein (hs-CRP).
- Measured ED using coronary flow reserve (CFR).
Main Results:
- fTx-HD patients had significantly lower serum albumin and CFR, and higher hs-CRP levels compared to nHD patients.
- Serum hs-CRP negatively correlated with CFR, while serum albumin positively correlated with CFR.
- No significant differences in age, gender, blood pressure, or dialysis adequacy (Kt/V) were observed between groups.
Conclusions:
- Endothelial dysfunction is more prevalent in fTx-HD patients than in nHD patients.
- Inflammation associated with failed renal allografts may contribute to endothelial dysfunction in fTx-HD patients.
Related Concept Videos
01:25Hemodialysis I: Introduction
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
01:27Dialysis
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
01:25Hemodialysis III: Nursing Management
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this measurement...
01:24Hemodialysis II: Procedure and Complications
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...