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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Allergic Reactions02:06

Allergic Reactions

Overview
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Updated: Jun 18, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
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Correlation between eosinophilic oesophagitis and aeroallergens.

F J Moawad1, G R Veerappan, J M Lake

  • 1Gastroenterology Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307, USA. fouad.moawad@amedd.army.mil

Alimentary Pharmacology & Therapeutics
|November 21, 2009
PubMed
Summary

Eosinophilic oesophagitis diagnoses show seasonal variation, peaking in spring and correlating significantly with grass pollen counts. This suggests aeroallergens play a role in the condition

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Last Updated: Jun 18, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Area of Science:

  • Gastroenterology
  • Allergy and Immunology
  • Environmental Health

Background:

  • Aeroallergens are suspected contributors to eosinophilic oesophagitis (EoE) pathogenesis.
  • Understanding environmental triggers is crucial for managing EoE.

Purpose of the Study:

  • To investigate seasonal patterns in EoE diagnoses.
  • To determine the correlation between EoE diagnoses and seasonal pollen counts.

Main Methods:

  • Retrospective analysis of 127 EoE cases diagnosed between January 2006 and November 2008.
  • Classification of cases by endoscopic date and collation of seasonal diagnoses.
  • Comparison of seasonal EoE case percentages with daily grass, tree, and weed pollen counts.

Main Results:

  • A peak in EoE diagnoses (33.0%) occurred in spring, with a low in winter (16%).
  • A strong positive correlation was found between the percentage of EoE cases diagnosed seasonally and mean grass pollen counts (r(s) = 1.000, P < 0.01).
  • No significant correlation was observed with tree or weed pollen counts.

Conclusions:

  • Eosinophilic oesophagitis diagnosis exhibits seasonal variation.
  • The findings support a link between seasonal pollen exposure, particularly grass pollen, and EoE diagnosis.
  • Aeroallergens are implicated as potential contributors to EoE pathogenesis.