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Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...

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Updated: Jun 18, 2026

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
04:48

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

Published on: January 7, 2015

Cetuximab-induced cutaneous toxicity.

H Tomková1, M Kohoutek, M Zábojníková

  • 1Department of Dermatology, T Bata's Regional Hospital, Zlin, Czech Republic. tomkovah@hotmail.com

Journal of the European Academy of Dermatology and Venereology : JEADV
|November 21, 2009
PubMed
Summary
This summary is machine-generated.

Cetuximab, an epidermal growth factor receptor inhibitor, frequently causes acneiform rash in cancer patients. This study reviewed cetuximab

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High-Throughput In Vitro Assay using Patient-Derived Tumor Organoids
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Last Updated: Jun 18, 2026

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
04:48

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Published on: January 7, 2015

High-Throughput In Vitro Assay using Patient-Derived Tumor Organoids
06:25

High-Throughput In Vitro Assay using Patient-Derived Tumor Organoids

Published on: June 14, 2021

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Epidermal growth factor receptor (EGFR) inhibitors are used for advanced malignancies.
  • These inhibitors are associated with significant cutaneous adverse reactions.
  • Understanding these toxicities is crucial for patient management.

Purpose of the Study:

  • To systematically review the cutaneous toxicity associated with cetuximab treatment.
  • To analyze the clinical characteristics and adverse events in patients receiving cetuximab.

Main Methods:

  • A retrospective analysis of 24 patients treated with cetuximab.
  • Patients included those with head and neck cancer and colorectal cancer.
  • Clinical characteristics and adverse events were documented.

Main Results:

  • Acneiform rash (pustular or maculopapular follicular eruption) occurred in 91.7% of patients.
  • Paronychia was observed in 4.2% of patients.
  • Radiation dermatitis and xerosis were noted in head and neck cancer patients receiving combination therapy; anaphylactic reactions occurred in 12.5%.

Conclusions:

  • Acneiform eruption is the most frequent cutaneous side effect of cetuximab.
  • Gender influenced the distribution of acneiform rash, with men experiencing more widespread lesions.
  • No association was found between eruption severity and treatment response.