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Related Experiment Video

Updated: Jun 18, 2026

Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology
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Abnormalities in brain structure and behavior in GSK-3alpha mutant mice.

Oksana Kaidanovich-Beilin1, Tatiana V Lipina, Keizo Takao

  • 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada. beilin@lunenfeld.ca

Molecular Brain
|November 21, 2009
PubMed
Summary

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Mice lacking the Glycogen synthase kinase-3 alpha (GSK-3alpha) gene show altered brain function, including impaired motor coordination and social behavior. These findings suggest GSK-3alpha

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Glycogen synthase kinase-3 (GSK-3) is a crucial serine/threonine protein kinase with two forms, GSK-3alpha and GSK-3beta.
  • GSK-3alpha knockout (KO) mice are viable and exhibit insulin sensitivity.
  • This study investigates the central nervous system (CNS) functions of GSK-3alpha KO mice.

Purpose of the Study:

  • To characterize the behavioral, neurochemical, and neuroanatomical alterations in GSK-3alpha KO mice.
  • To elucidate the role of GSK-3alpha in brain function and behavior.

Main Methods:

  • Utilized a comprehensive battery of behavioral tests in GSK-3alpha KO mice.
  • Conducted neurochemical and neuroanatomical analyses.
  • Assessed motor coordination, social behavior, learning, and memory.

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Last Updated: Jun 18, 2026

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Main Results:

  • GSK-3alpha KO mice displayed reduced exploratory and aggressive behaviors, decreased locomotion, and impaired motor coordination.
  • Mutant mice showed deficits in social motivation, enhanced sensorimotor gating, and impaired associated memory.
  • Significant structural and functional changes were observed in the cerebellum, including reduced Purkinje cell numbers and size.

Conclusions:

  • The GSK-3alpha gene plays a significant role in CNS functioning.
  • Dysregulation of GSK-3alpha may be implicated in the pathophysiology of psychiatric disorders.