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Related Experiment Video

Updated: Jun 18, 2026

Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood Using the STEMCCA Lentiviral Vector
12:03

Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood Using the STEMCCA Lentiviral Vector

Published on: October 31, 2012

[Stem cell harvesting after plerixafor treatment].

Per Boye Hansen1, Eva Gaarsdal

  • 1Medicinsk Haematologisk Afdeling L, Herlev Hospital, DK-2730 Herlev, Denmark. peboha01@heh.regionh.dk

Ugeskrift for Laeger
|November 21, 2009
PubMed
Summary

Plerixafor, a novel stem cell factor, successfully mobilized hematopoietic stem cells for transplantation in a patient with mantle cell lymphoma when standard methods failed. This offers a new option for stem cell harvesting in challenging cases.

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An immunogenic first-in-human immune modulatory vaccine with PD-L1 and PD-L2 peptides is feasible and shows early signs of efficacy in follicular lymphoma.

Oncoimmunology·2024
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Ugeskrift for laeger·2023
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Retraction Note to: Bismuth adjuvant ameliorates adverse effects of high-dose chemotherapy in patients with multiple myeloma and malignant lymphoma undergoing autologous stem cell transplantation: a randomised, double-blind, prospective pilot study.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2020
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Bismuth adjuvant ameliorates adverse effects of high-dose chemotherapy in patients with multiple myeloma and malignant lymphoma undergoing autologous stem cell transplantation: a randomised, double-blind, prospective pilot study.

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[A 87-year-old woman was run down by a hit-and-run driver and cured of malignant lymphoma].

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[Malignant lymphoma complicated with posterior reversible encephalopathy].

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Area of Science:

  • Hematology
  • Oncology
  • Pharmacology

Background:

  • Mantle cell lymphoma treatment often involves autologous stem cell transplantation.
  • Mobilization of hematopoietic stem cells is crucial for successful transplantation.
  • Standard mobilization protocols may not be effective in all patients.

Observation:

  • A 66-year-old male with mantle cell lymphoma failed to mobilize sufficient stem cells using chemotherapy and filgrastim.
  • Plerixafor, a CXCR4 antagonist, was administered after obtaining regulatory approval.
  • The patient received filgrastim followed by plerixafor for stem cell mobilization.

Findings:

  • Plerixafor, in combination with filgrastim, enabled successful harvesting of adequate hematopoietic stem cells.
  • This approach overcame the mobilization failure encountered with standard treatments.

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Published on: July 16, 2011

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Last Updated: Jun 18, 2026

Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood Using the STEMCCA Lentiviral Vector
12:03

Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood Using the STEMCCA Lentiviral Vector

Published on: October 31, 2012

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells
14:22

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells

Published on: July 16, 2011

  • Sufficient stem cells were collected for autologous stem cell transplantation.

    • Implications:

    • Plerixafor represents a viable alternative for stem cell mobilization in patients unresponsive to conventional therapies.
    • This finding expands therapeutic options for patients undergoing autologous stem cell transplantation.
    • Further research may explore plerixafor's efficacy in diverse patient populations and lymphoma subtypes.