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Updated: Jun 18, 2026
10:44
Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
Published on: May 15, 2019
[Thalidomide therapy for gastrointestinal angiodysplasia]
Erika Bélard1, Catherine H Foss, Lisbeth Ambrosius Christensen
1Hvidovre Hospital, Gastroenheden, Medicinsk Afsnit, Denmark. erika_belard@hotmail.com
Ugeskrift for Laeger
|November 21, 2009
Summary
Obscure recurrent intestinal bleeding, often caused by angiodysplasia, presents a challenge. Thalidomide offers a successful treatment option for patients refractory to standard therapies.
Area of Science:
- Gastroenterology
- Vascular Medicine
Background:
- Obscure recurrent intestinal bleeding (ORIB) is a significant clinical problem.
- Angiodysplasia is a common cause of ORIB, often requiring extensive diagnostic and therapeutic interventions.
Observation:
- Two patients with ORIB refractory to conventional treatments were identified.
- These patients had undergone multiple prior procedures without sustained relief.
Findings:
- Both patients demonstrated a successful clinical response following treatment with Thalidomide.
- Thalidomide effectively controlled the intestinal bleeding in these refractory cases.
Implications:
- Thalidomide represents a potential therapeutic option for managing ORIB due to angiodysplasia.
- This finding may guide future treatment strategies for patients with difficult-to-treat intestinal bleeding.
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