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In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
Published on: October 25, 2024
Peripheral Th-17 cells in allergic rhinitis: New evidence
Giorgio Ciprandi1, Gilberto Filaci, Florinda Battaglia
1Department of Internal Medicine - C.E.B.R., University of Genoa, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy. gio.cip@libero.it
International Immunopharmacology
|November 21, 2009
Summary
Patients with allergic rhinitis exhibit increased frequencies of T helper 17 (Th17) cells, which are involved in inflammatory responses. This suggests a potential role for Th17 cells in allergic reactions to pollens.
Area of Science:
- Immunology
- Allergy Research
Background:
- T helper 17 (Th17) cells are key players in inflammatory processes.
- Elevated serum Interleukin-17 (IL-17) levels have been observed in severe birch pollen allergy.
- Understanding Th17 cell involvement in allergic rhinitis is crucial.
Purpose of the Study:
- To compare the cytokine profiles of patients with allergic rhinitis.
- To determine the frequency of peripheral allergen-specific T helper cells producing IL-17.
- To investigate the role of Th17 cells in allergic rhinitis.
Main Methods:
- Evaluated 12 patients with persistent allergic rhinitis and 5 healthy controls during pollen season.
- Assessed Th17 cells via intracellular staining in ex-vivo T cell compartments.
- Analyzed T cells after short activation with allergens and control antigens.
Main Results:
- Allergic patients showed higher frequencies of IL-17 producing T cells ex-vivo.
- Functional analysis confirmed increased IL-17 producing T cells in allergic patients post-allergen stimulation.
- Peripheral blood mononuclear cell (PBMC) evaluation supported these findings.
Conclusions:
- This preliminary study highlights the potential involvement of Th17 cells in allergic responses.
- Findings suggest Th17 cells may play a significant role in allergic rhinitis.
- Further research is warranted to elucidate the precise mechanisms.
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