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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Automated Microbial Diagnostics01:24

Automated Microbial Diagnostics

Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...

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Amplicon Sequencing using the Long-Read Sequencing Technologies
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Amplicon Sequencing using the Long-Read Sequencing Technologies

Published on: August 29, 2025

Novel and improved technologies for tuberculosis diagnosis: progress and challenges.

Madhukar Pai1, Jessica Minion, Hojoon Sohn

  • 1Department of Epidemiology, Biostatistics & Occupational Health, McGill University, 1020 Pine Avenue West, Montreal, H3A 1A2, Canada. madhukar.pai@mcgill.ca

Clinics in Chest Medicine
|November 21, 2009
PubMed
Summary

Accurate tuberculosis (TB) diagnosis and case detection are crucial for TB control. This review examines current TB diagnostic evidence, new technologies, and cost-effectiveness to improve global TB management.

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Last Updated: Jun 18, 2026

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Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test
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Published on: April 9, 2012

Area of Science:

  • Microbiology
  • Public Health
  • Medical Diagnostics

Background:

  • Tuberculosis (TB) control efforts have improved cure rates over the last decade.
  • Diagnosis and effective case detection remain significant challenges in global TB control strategies.

Purpose of the Study:

  • To review the current evidence base for tuberculosis diagnostics.
  • To describe the advancements in new diagnostic technologies for TB.
  • To analyze cost-effectiveness and modeling studies on the impact of novel diagnostics in TB control.

Main Methods:

  • Literature review of existing evidence on TB diagnostics.
  • Assessment of progress in novel diagnostic technologies.
  • Analysis of cost-effectiveness and modeling studies.

Main Results:

  • Diagnostic challenges persist despite progress in TB treatment.
  • New diagnostic technologies are emerging with potential to improve case detection.
  • Cost-effectiveness studies indicate the potential impact of new diagnostics on TB control.

Conclusions:

  • Improving TB diagnosis and case detection is essential for effective TB control.
  • Advancements in diagnostic technology offer promising solutions.
  • Economic evaluations are vital for implementing new diagnostics in public health strategies.