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Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Preventive Healthcare Services01:30

Preventive Healthcare Services

Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

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System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

Screening and preventive therapy for tuberculosis.

Ben J Marais1, Helen Ayles, Stephen M Graham

  • 1Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg 7505, South Africa. bjmarais@sun.ac.za

Clinics in Chest Medicine
|November 21, 2009
PubMed
Summary
This summary is machine-generated.

Tuberculosis (TB) control focuses on eradication in developed nations by preventing latent infection reactivation. In developing countries, TB control is poor, especially with HIV, necessitating a critical assessment of preventive therapy approaches.

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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
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Last Updated: Jun 18, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
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Published on: April 5, 2017

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

Area of Science:

  • Public Health
  • Infectious Diseases
  • Epidemiology

Background:

  • Tuberculosis (TB) is largely controlled in developed countries, with efforts shifting towards eradication.
  • Reactivation of latent infection is the primary cause of TB in non-endemic areas.
  • TB control is significantly poorer in developing nations, often exacerbated by poverty and HIV co-infection.

Purpose of the Study:

  • To critically assess the current approaches to tuberculosis preventive therapy in both children and adults.
  • To examine the treatment rationale and available data for TB preventive therapy.
  • To identify key issues and concerns regarding the implementation of TB preventive therapy.

Main Methods:

  • This review critically assesses existing literature and data on tuberculosis preventive therapy.
  • The authors focus on the underlying treatment rationale and evidence base.
  • The review identifies challenges and areas for improvement in TB preventive therapy strategies.

Main Results:

  • Preventive therapy, with adequate resources, can aid in eliminating latent infection pools for TB eradication in developed settings.
  • Significant challenges persist in TB control in developing countries, particularly those with high HIV prevalence.
  • The review highlights specific concerns and data gaps related to TB preventive therapy in diverse populations.

Conclusions:

  • Effective TB eradication strategies in developed countries rely on preventing latent infection reactivation through widespread preventive therapy.
  • Addressing the TB epidemic in developing countries requires improved control strategies, especially for vulnerable populations affected by HIV.
  • Further critical assessment and targeted interventions are needed to optimize TB preventive therapy globally.