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White matter hyperintensities and cognition: testing the reserve hypothesis.

Adam M Brickman1, Karen L Siedlecki, Jordan Muraskin

  • 1Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. amb2139@columbia.edu

Neurobiology of Aging
|November 21, 2009
PubMed
Summary

Higher brain and cognitive reserve allow individuals to tolerate more white matter hyperintensities (WMH) before impacting cognition. This suggests reserve mitigates the effects of brain pathology.

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