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Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives

Sham M Sondhi1, Jaiveer Singh, Reshma Rani

  • 1Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667 UK, India. sondifcy@iitr.ernet.in

European Journal of Medicinal Chemistry
|November 21, 2009
PubMed

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Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
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Aryldiazonium Salts to Azo Dyes: Diazo Coupling

The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para position.