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Published on: March 27, 2018
The association between alcohol consumption and morbidity and mortality in patients undergoing coronary artery bypass
Ankit Maheshwari1, Jarrod E Dalton, Jean-Pierre Yared
1Department of Outcomes Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. mahesha@ccf.org
Insights
Moderate alcohol consumption (3+ drinks/week) did not improve postoperative outcomes in patients undergoing coronary artery bypass graft (CABG) surgery. This study found no significant association between regular alcohol intake and surgical complications or hospital stay.
Area of Science:
- Cardiovascular Surgery
- Alcohol Consumption Research
- Perioperative Medicine
Background:
- Moderate alcohol consumption is linked to reduced cardiovascular events in population studies.
- Its impact on perioperative outcomes, particularly after coronary artery bypass graft (CABG) surgery, remains unclear.
Purpose of the Study:
- To investigate the hypothesis that consuming 3 or more alcoholic drinks per week improves postoperative outcomes in patients undergoing CABG surgery.
Main Methods:
- A propensity-matched retrospective cohort study analyzed data from 13,065 patients undergoing elective CABG surgery.
- Patients were matched based on propensity scores to compare alcohol users with infrequent/nonusers.
- Outcomes assessed included a composite of major morbidities and mortality, and hospital length of stay.
Main Results:
- Patients consuming at least 3 drinks per week showed similar odds of the composite outcome compared to infrequent or nonusers (adjusted OR, 1.13; P=0.14).
- Hospital length of stay was also not significantly related to alcohol consumption (adjusted HR, 1.03; P=0.28).
Conclusions:
- Alcohol consumption of 3 or more drinks per week was not associated with a reduced risk of postoperative complications in CABG patients.
- The study did not differentiate alcohol abusers, and findings may not apply to this group.
Objective:
Moderate alcohol consumption appears protective against cardiovascular events and mortality in community-based epidemiologic studies, but whether its consumption affects perioperative outcomes remains unknown. Therefore, the authors tested the hypothesis that alcohol consumption of 3 or more drinks per week improves postoperative outcomes in patients undergoing coronary artery bypass graft (CABG) surgery.
Design:
A propensity-matched retrospective cohort study.
Setting:
A major cardiovascular surgical institute, tertiary care teaching hospital.
Participants:
Data from 13,065 patients undergoing elective CABG surgery at the Cleveland Clinic were analyzed.
Interventions:
None.
Measurements And Main Results:
Propensity scores were used to match alcohol users with infrequent/nonusers. From the matched subset, the relationship between alcohol use and the composite outcome (any major cardiac, renal, respiratory, infectious, or neurologic morbidity and mortality) was determined univariably with the Pearson chi-square test and multivariably using stepwise logistic regression. Estimation of the relationship between such alcohol use and hospital length of stay was of secondary interest. Patients who reported consuming at least 3 drinks per week experienced similar odds of the composite outcome (adjusted odds ratio [95% confidence interval] of 1.13 [0.96-1.34], p = 0.14) to infrequent or nonusers. In a secondary analysis, the hospital length of stay was unrelated to alcohol use (adjusted hazard ratio [95% CI] of 1.03 [0.97-1.09], p = 0.28).
Conclusion:
The present results showed that alcohol consumption was not associated with the risk for postoperative complications in patients undergoing CABG surgery. Alcohol abusers could not be separated in this study, and, based on previous literature, this result might not be applied to them.
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